NAHR

CNVs: NAHR (Non Allelic Homologous Recombination)

ON DIFFERENT ALLELES Expanding the topic about CNVs formation: beyond evolution, it is necessary to talk about NAHR: NAHR (Non Allelic Homologous Recombination) Homologous recombination (HR) guides the exchange of genomic material during the meiosis contributing to human inter individual variation. HR takes place between two allelic homologous regions (e.g. between two regions located at the

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CNVs formation: beyond evolution

BEYOND EVOLUTION LCRs/DSs cause CNVs Mechanisms of DNA replication and repair are the basis for the formation of CNVs. CNVs formation is also strictly dependent from the action of some particular genomic regions called low copy repeats (LCRs) or segmental duplications (SDs). LCRs/SDs are tracts of duplicated DNA which are comprised between 1 and 400

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Multi-allelic CNVs (mCNVs)

mCNVs: YET TO BE DISCOVERED Several hundreds of human genomic traits (and maybe even more) show CNVs (Copy Number Variations) within a very large range of alleles. Such CNVs are also called multi-allelic CNVs (mCNVs). Non-Allelic Homologous Recombination (NAHR) mCNVs can evolve with mechanism of non-allelic homologous recombination (NAHR) at a much higher mutational rate than SNPs

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