Y-Chromosome microdeletions

Description

Azoospermia factors deletion testing

Andrologists often request Y-chromosome microdeletions in infertile men to ascertain the cause of azoospermia. The test checks the loss of a specific region of the Y-chromosome where the so-called “azoospermia factor” (AZFa, b, and c) are located. Deletions in this chromosomal region remove one or more candidate genes (DAZ, RBMY, USP9Y, and DBY) and cause severe testiculopathy leading to male infertility. These deletions are present in as many as 5% and 10% of severe oligospermic and azoospermic men.

Technical specifications

Method

MLPA

Sample specifications

DNA (at least 1 μg), whole-blood in EDTA (purple cap tubes).

Timing

2-3 weeks.

Availability

Per Professionisti e Laboratori: registrati qui per inserire il tuo 1-minute online order. Per Pazienti: inviare una richiesta a info@bredagenetics.com

Limitations

The test detects deletions of the azoospermia factor region only. Oligospermia and azoospermia may be caused by other causes, not identifiable by this test.

Advice

To learn more about male infertility, read our post Genetics of male infertility

Other

At partner clinical laboratories. Genetic Counseling required to access the test (book it by us today).

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No minimum number of samples required!

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