Thrombophilia

Description

Rapid thrombophilia testing through F2 gene (Prothrombin) and F5 (Factor V Leiden) analysis

Prothrombin and Factor V Leiden testing

Thrombophilia testing is required by many fertility centers and Recurrent Pregnancy Loss (RPL) specialists. In most cases, Prothrombin (i.e., the G20210A variant in the F2 gene) and Factor V Leiden (i.e., the G1691A variant in the F5 gene) are requested.

Although their relevance to the risk of pregnancy loss is limited, testing may be useful to define the thrombophilic risking for other circumstances. The MTHFR thermolabile polymorphisms (A1298C and C677T) may also be requested and are available for testing, although their role in the human thrombophilic risk is irrelevant and their testing should be discouraged (ACMG statement 2009).

Technical specifications

Method

Sequencing

Sample specifications

1 ml of whole peripheral blood in an EDTA tube (purple cap). No fasting required.

Timing

2 weeks

Availability

Per Professionisti e Laboratori: registrati qui per inserire il tuo 1-minute online order. Per Pazienti: inviare una richiesta a info@bredagenetics.com

Limitations

Only the polymorphism G20210A in the F2 gene and/or the polymorphism G1691A in the F5 gene (Factor V Leiden) are tested. All other possible gene variants will not be scanned.

Advice

To know all about Factor V Leiden, read our dedicated post!

Please note: The Prothrombin G20210A polymorphisms and Factor V Leiden are NOT risking factors for approved COVID-19 vaccines!

Other

In service at partner Clinical Laboratories – Genetic Counseling required to access the test (book it online with us!)

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No minimum number of samples required!

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