MLPA (Multiplex Ligation-Dependent Probe Amplification) is available at Breda Genetics to offer you the widest selection of genes at the best turnaround time.

Molecular deletion/duplication testing

A molecular assay such as MLPA may be necessary to safely scan for large exonic, multi-exonic or whole-gene deletions in certain genes. Similarly, it may help confirm a large deletion or duplication detected by algorithmic CNV analysis at Whole Exome Sequencing and Whole Genome Sequencing.

A wide selection of available kits

MLPA analysis can be performed by utilizing commercial kits, of which availability is usually scattered among different laboratories. Thanks to our network of partner labs, we can always find the right kit for the gene of your interest.

MS-MLPA (UPD testing)

Methylation-Specific MLPA (MS-MLPA) for Uniparental Disomy (UPD) can also be requested for conditions characterized by the alteration of the methylation pattern, like for instance Silver-Russell, Prader-Willi, Angelman, Beckwith-Wiedemann syndromes and others.

Technical specifications


Exon-centric large deletion/duplication testing for single genes (or small subsets of genes) based on Multiplex Ligation-Dependent Probe Amplification (MLPA) on capillary electrophoresis.

Sample specifications

DNA (at least 1 μg), whole-blood in EDTA (purple cap tubes), dried blood spots (on Breda Genetics filter cards), Breda Genetics buccal swabs. Sample shipping is at room temperature (no dry-ice required! Free shipping included in your contract? Book sample collection directly from your customer’s area).


2-3 weeks in average (longer TATs may be required for certain genes).


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For some genes, MLPA probes may cover just a few exons and not all of them. Not all human genes are available for MLPA testing. For some genes, Research Use Only (RUO) kits might be available.


To learn more about MLPA, read the dedicated post in our knowledgebase.


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