Variant of Uncertain Significance (VUS): meaning, causes and interpretation
April 18 2026
What is a Variant of Uncertain Significance (VUS) A Variant of Uncertain Significance (VUS) is a genetic variant identified through genetic testing that cannot be clearly classified as either benign (not disease-causing) or pathogenic (disease-causing) based on the available evidence. VUS are commonly reported in tests such as gene panels, Whole Exome Sequencing (WES), or