Mutations in cancer development: drivers and passengers Those genetic mutations that drive the development of cancer are defined as driver mutations. Driver mutations allow cancer to grow and invade the human body. Several genetic mutations are found in cancer cells, however just a few can be classified as drivers. All other mutations, which play just a secondary role
HEREDITARY AND SPORADIC: THE GENETICS Hereditary diffuse gastric cancer is an autosomal dominant cancer predisposition syndrome. In addition to gastric cancer, up to 60% of female mutation carriers develop lobular carcinoma of the breast, and some carriers may develop colorectal cancer. Hereditary diffuse gastric cancer (HDGC) and lobular breast cancer (LBC) are caused by heterozygous
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