Assisted Reproductive Technology (ART) and neurodevelopmental disorders: is there an association?

Another hot question for Geneticists, Andrologists and Gynecologists: does Assisted Reproductive Technology (ART) increase the risk for neurodevelopmental disorders in newborns? The common conception is that, especially when doing Intra-Cytoplasmic Sperm Injection (ICSI), the natural barriers are skipped by the technology and abnormal germline cells (sperm or oocytes) that would be normally depleted, for instance […]

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Genetic testing in recurrent pregnancy loss: when and which

Of all the clinically recognized pregnancies, about 15% end in a miscarriage, making this event one of the most common adverse events. Unfortunately, about 2-5% of couples take on recurrent pregnancy loss (RPL). However, "Recurrent pregnancy loss" definition, which according to the European Society of Human Reproduction and Embryology is the presence of two or […]

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Sequencing machines: Roche 454

The first NGS platform Talking about the system of the Roche 454 means starting from the dawn of Next Generation Sequencing. The first three Next Generation Sequencing (NGS) platforms were produced by three independent companies which, a little later, were acquired by other industrial groups. System 454 is based on pyrosequencing, a technique based on […]

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